Deutsche Bank is to cut 1,920 jobs over the next two years from its domestic workforce of 27,330.
Germany's biggest bank said the cuts would be in administrative posts and would not affect its retail operation.
Deutsche Bank, which contracted out IT and clearing jobs in recent years, said there would be no forced redundancies.
German banks have been struggling to make money in a crowded home market. Rivals HVB Group and Commerzbank, have also announced restructuring plans.
The Deutsche Bank redundancies are part of an ongoing reorganisation of its global workforce of 65,000.
The bank said it would give details of international jobs cuts by February.